Bharat Biotech on Wednesday mentioned Covaxin didn’t include new child calf serum and it was not an ingredient used within the last formulation of the Covid-19 vaccine. The corporate was responding to social media posts on the composition of Covaxin which mentioned it contained new child calf serum.
“New child calf serum is used within the manufacturing of viral vaccines. It’s used for the expansion of cells, nevertheless it has neither been used within the progress of the SARS CoV2 virus, nor the ultimate formulation. Covaxin is extremely purified to include solely the inactivated virus parts by eradicating all different impurities. Bovine serum is broadly used within the manufacture of vaccines globally for a number of many years,” the corporate mentioned.
The utilization of new child calf serum was transparently documented in lots of publications during the last 9 months, it added.
The corporate defined that totally different sorts of bovine and different animal serum had been customary enrichment ingredient used globally for vero cell progress. Vero cells are used to determine cell traces that assist in the manufacturing of vaccines. This method has been used for many years in polio, rabies and influenza vaccines, the corporate mentioned.
The vero cells, after the expansion, are washed with water and chemical compounds many instances to make them free from the new child calf serum. Thereafter, these vero cells are contaminated with the coronavirus for viral progress. The vero cells are destroyed within the means of viral progress. The grown virus can be killed and purified. This killed virus is then used to make the ultimate vaccine, and within the last vaccine formulation no calf serum is used, the corporate mentioned.